Asante Kotoko lost for the second time to city rivals King Faisal within 25-days as they crashed out of the 2021/22 MTN FA Cup after losing 1-0 at the Baba Yara Stadium on Wednesday.

The Porcupine Warriors lost 3-2 to their neighbours on December 5 at the Baba Yara stadium in a Ghana Premier League contest.

The Round of 64 tie brought together two Premier League who sit neck to neck in the Premier League table after 10 rounds of matches.

King Faisal forward Baba Yahaya capitalised on Kotoko’s defensive mistakes to punish them as he went round Andrews Appau before slotting home for the opener.

Kotoko should have drawn level in the 38th-minute but George Mfegue shot feebly into the hands of King Faisal goalkeeper Frank Boateng.

Winger Mawuli Wayo's effort three minutes later was shielded by Mubarik Yusif to stop Faisal from doubling their lead.

Kotoko coach Prosper Narteh Ogum brought on Joseph Amoako and Christopher Nettey for George Mfegue and Sheriff Mohammed.

Asante Kotoko made some decent incursions in search of the equalizer but Faisal was up to the task in every instance.

Asante Kotoko shot-stopper Danlad Ibrahim was busy on the day as he pulled a save from Evans Sarfo to keep the scoreline unchanged.

The exchanges between the two sides failed to produce goals as King Faisal held on to win 1-0 at the Baba Yara Stadium to progress to the Round of 32 of the MTN FA Cup.

Elsewhere in Kpando Heart of Lions progressed to the round of 32 after beating WAFA 4-3 on penalties at the Kpando Sports Park.

Emmanuel Gyan scored in the 8th minute for the Lions.

But the Academy Boys forced the game into penalty shootouts when they snatched the equalizer on the 90th minute.

Karela United FC also progressed to the next round after beating rivals Medeama SC 5-4 on penalties following a 2-2 draw in regulation time.

Amed Toure opened the scoring for the visitors 22 minutes before Samuel Kumi pulled parity for Karela United.

Medeama restored their lead through Ansu Kofi Patrick in the 32nd minute but that lead lasted for only seven minutes as Umar Bashiru scored from the spot bring the home side level.

The second did not produce a winner as they went into a shootout.

Other Round of 64 results:

Tema Youth 1-Legon Cities 1 (Legon Cities won 4-2 on penalties)

Unity Stars 1 – Berekum Chelsea 2

AshantiGold 1 – Bechem United 2

Elmina Sharks 3 – Achiken FC 2

Tamale City 3 – Steadfast FC 1

Holders Hearts of Oak progressed to the Round of 32 after beating Accra Lions 1-0 at the Carl Reindorf Park.

Aduana FC 4 – Eleven Wonders 1

Real Atletico 1 – Great Olympics 1 (Real Atletico won 3-1 on penalties)

Dreams Tamale 1 – Real Tamale United 1 (Real Tamale United won 4-2 on penalties)

Hasaacas 0 – Gold Stars 1

Koforidua Suhyen 1 – First Klass 2

Berekum Arsenal 0 – Young Apostles 0 (Young Apostles won 5-4 on penalties)